{"id":12650,"date":"2026-01-19T08:38:25","date_gmt":"2026-01-19T07:38:25","guid":{"rendered":"https:\/\/glutenlight.eu\/?p=12650"},"modified":"2026-01-26T09:39:52","modified_gmt":"2026-01-26T08:39:52","slug":"irritable-bowel-syndrome-ibs-and-intestinal-permeability","status":"publish","type":"post","link":"https:\/\/glutenlight.eu\/?p=12650&lang=en","title":{"rendered":"Irritable Bowel Syndrome (IBS) and Intestinal Permeability"},"content":{"rendered":"

Abstract<\/strong>
\nIrritable bowel syndrome (IBS) is a complex and multifactorial disorder that cannot be explained by a single pathogenic mechanism. In recent years, increased intestinal permeability (\u201cleaky gut\u201d) has received considerable attention as a potential contributor to IBS pathophysiology. However, current scientific evidence indicates that barrier dysfunction affects only a subset of patients rather than representing a universal feature of the condition. Increased intestinal permeability is more frequently observed in diarrhea-predominant IBS (IBS-D) and post-infectious IBS (PI-IBS), whereas many patients exhibit a structurally intact intestinal barrier. In these cases, symptoms are more accurately attributed to alterations in the gut\u2013brain axis, visceral hypersensitivity, disordered intestinal motility, and gut microbiota dysbiosis. An integrated understanding of these mechanisms is essential to move beyond reductionist models and to guide personalized therapeutic strategies.<\/p>\n

Keywords<\/strong>
\nirritable bowel syndrome, IBS, intestinal permeability, leaky gut, IBS-D, post-infectious IBS, gut barrier, tight junctions, gut-brain axis, visceral hypersensitivity, gut microbiota, functional gastrointestinal disorders, chronic abdominal pain, low-grade inflammation, personalized IBS treatment<\/p>\n

1. Introduction<\/strong>
\nIrritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders, characterized by recurrent abdominal pain associated with changes in bowel habits, in the absence of identifiable structural abnormalities. Over the past two decades, the traditional view of IBS as a purely \u201cfunctional\u201d disorder has been progressively replaced by a more comprehensive model that integrates neurobiological, immune, microbial, and mucosal barrier factors.
\nWithin this evolving framework, increased intestinal permeability\u2014commonly referred to as \u201cleaky gut\u201d\u2014has been proposed as a central mechanism in IBS pathogenesis. While this hypothesis has gained substantial attention, accumulating evidence suggests a more nuanced reality: increased permeability is present only in a subset of IBS patients and does not constitute a defining feature of the syndrome as a whole.<\/p>\n

2. Evidence of Altered Intestinal Permeability in IBS<\/strong>
\nNumerous clinical and experimental studies have assessed intestinal barrier function in IBS using permeability tests (e.g., lactulose\/mannitol ratio), urinary and plasma biomarkers, mucosal biopsies, and molecular analyses of tight junction proteins.
\nCollectively, these studies demonstrate that:
\nA significant but non-majority proportion of IBS patients exhibits increased intestinal permeability;
\nBarrier dysfunction is more commonly observed in the colon, although small intestinal involvement may occur in specific subgroups;
\nIncreased permeability is not stable over time and may fluctuate in response to prior infections, dietary factors, psychological stress, and microbiota composition.
\nThese findings indicate that intestinal barrier dysfunction represents an important pathogenic mechanism in IBS, but not an exclusive or universal one.<\/p>\n

3. Differences Among IBS Subtypes<\/strong>
\nThe heterogeneity of IBS becomes particularly evident when examining its clinical subtypes:
\nIBS-D (diarrhea-predominant IBS): This subtype is most frequently associated with increased intestinal permeability. Alterations in tight junction proteins and enhanced immune exposure to luminal antigens have been consistently reported.
\nPost-infectious IBS (PI-IBS): PI-IBS represents one of the strongest models linking IBS to barrier dysfunction. Following acute gastroenteritis, some patients develop chronic symptoms associated with increased permeability, low-grade mucosal inflammation, and mast cell activation.
\nIBS-C (constipation-predominant IBS): In most studies, intestinal permeability in IBS-C patients is comparable to that of healthy controls.
\nIBS-M (mixed subtype): Barrier function appears most consistently preserved in this group.
\nThese differences underscore the absence of a single biological phenotype underlying IBS.<\/p>\n

4. Molecular Mechanisms of Barrier Dysfunction<\/strong>
\nIn IBS patients with increased permeability, several structural and functional alterations of the intestinal epithelial barrier have been documented, including:
\nReduced expression or disorganization of tight junction proteins such as ZO-1, occludin, and claudins;
\nIncreased paracellular passage of luminal molecules and antigens;
\nA correlation between the degree of barrier impairment and the severity of abdominal pain.
\nLoss of epithelial integrity facilitates contact between luminal antigens (bacterial or dietary) and the mucosal immune system, contributing to low-grade inflammatory responses.<\/p>\n

5. Interaction Between Intestinal Permeability, Immune System, and Microbiota<\/strong>
\nIn IBS subgroups characterized by barrier dysfunction, increased permeability may initiate a pathogenic cascade involving:
\nActivation of mast cells and other immune cells within the lamina propria;
\nRelease of inflammatory and neuroactive mediators;
\nSensitization of enteric nerve endings.
\nThe gut microbiota plays a central role in this process. Qualitative and functional alterations of microbial communities can both contribute to barrier dysfunction and amplify immune and neural responses. Nevertheless, these mechanisms are not present in all IBS patients, reinforcing the concept of biological heterogeneity.<\/p>\n

6. IBS Without Increased Intestinal Permeability<\/strong>
\nA crucial and often underestimated aspect of IBS is that many patients exhibit a structurally intact intestinal barrier. This is well documented in IBS-C and IBS-M subtypes, but also applies to a proportion of IBS-D patients.
\nIn such cases, the leaky gut model alone is insufficient to explain symptom generation.<\/p>\n

7. Alternative Mechanisms Independent of Permeability<\/strong>
\n7.1 Gut\u2013Brain Axis Dysfunction
\nIBS is currently classified as a disorder of gut\u2013brain interaction. Altered bidirectional communication between the enteric nervous system and the central nervous system can generate pain, urgency, and bowel habit changes in the absence of mucosal damage.
\n7.2 Visceral Hypersensitivity
\nMany IBS patients exhibit a reduced pain threshold to physiological intestinal stimuli. This phenomenon is attributed to:
\nPeripheral neural sensitization;
\nCentral amplification of nociceptive signaling.
\n7.3 Altered Intestinal Motility
\nDisruptions in intestinal motor patterns may account for diarrhea, constipation, or alternating bowel habits without involving epithelial barrier dysfunction.
\n7.4 Dysbiosis Independent of Barrier Damage
\nGut microbiota alterations may influence fermentation, gas production, bile acid metabolism, and neuroendocrine signaling even when intestinal permeability remains normal.<\/p>\n

8. Clinical and Therapeutic Implications<\/strong>
\nRecognizing the heterogeneity of IBS has important clinical consequences:
\nIn IBS-D and PI-IBS patients with documented increased permeability, interventions targeting barrier function (e.g., low-FODMAP diet, microbiota modulation, mucosal protective strategies) may be particularly beneficial;
\nIn patients with normal permeability, therapeutic approaches focused on the gut\u2013brain axis, visceral sensitivity modulation, and stress management are likely more appropriate.
\nA personalized approach is therefore essential.<\/p>\n

9. Conclusions<\/strong>
\nIBS is a multifactorial and biologically heterogeneous condition. Increased intestinal permeability represents a documented and clinically relevant pathogenic mechanism, but it is not universal. In many patients, symptoms arise from neurofunctional, motor, or microbial alterations in the presence of an intact intestinal barrier.
\nAn integrated perspective allows clinicians and researchers to move beyond reductionist models and to develop more effective diagnostic and therapeutic strategies.
\nThe inflammatory, neurofunctional, microbial, and barrier-related mechanisms discussed here are explored in greater detail in the related articles referenced below.<\/p>\n

Commented Bibliographic References (for Further Reading)<\/strong>
\n1. Camilleri M. et al. \u2013 Review on IBS and intestinal barrier function
\nA critical analysis of permeability alterations across IBS subtypes, emphasizing their non-universality.
\n2. Bischoff S.C. et al. \u2013 Intestinal permeability: mechanisms and clinical relevance
\nA foundational reference on molecular mechanisms of barrier function and clinical implications.
\n3. Spiller R., Garsed K. \u2013 Post-infectious IBS . Describes PI-IBS as a key model linking low-grade inflammation and increased permeability.
\n4. Barbara G. et al. \u2013 Mast cells and IBS. Seminal work on mast cell involvement in visceral pain and hypersensitivity.
\n5. Ford A.C. et al. \u2013 Systematic reviews on IBS pathophysiology
\nIntegrated overview of microbiota, motility, and gut\u2013brain axis mechanisms.
\n6. Drossman D.A. \u2013 Disorders of gut\u2013brain interaction. A cornerstone reference framing IBS within modern gut\u2013brain interaction paradigms.<\/p>\n

The different mechanisms discussed\u2014inflammatory, neuro-functional, microbial, and barrier-related\u2014are examined separately in the related articles.<\/strong><\/span><\/p>\n

<\/p>\n

Related Articles<\/strong><\/p>\n

1. Irritable Bowel Syndrome: why inflammation and \u201cleaky gut\u201d are not the same thing<\/a>
\n2. Irritable bowel syndrome, intestinal permeability, and chronic low-grade inflammation \u2014 Scientific review<\/a>
\n\"\"\"\"\"\"<\/a>3 –\u00a0\"\"\"\"Undigested food\u00a0\u2192 <\/strong>Low-Grade Intestinal Inflammation \u2192 Increased Intestinal Permeability<\/a>
\n4. Molecular mechanisms linking intestinal permeability, tight junctions, and microbiota in irritable bowel syndrome (IBS)
\n5. Biomarkers involved in the link between chronic low-grade inflammation and intestinal permeability
\n6. Genetic and epigenetic factors in irritable bowel syndrome (IBS)<\/p>\n

Integrated synthesis of IBS pathophysiological mechanisms and related articles
\nThis appendix provides a cross-sectional synthesis of the main pathophysiological mechanisms of IBS, integrating and contextualizing the individual in-depth articles listed in the main text.<\/p>\n

Irritable Bowel Syndrome (IBS) and related articles: synthesis
\nIntroduction
\nIrritable bowel syndrome (IBS) is a chronic disorder of the digestive tract characterized by recurrent abdominal pain, cramps, bloating, gas, constipation and\/or diarrhea, in the absence of evident structural intestinal damage. IBS is a multifactorial disorder: symptoms may arise from increased intestinal permeability, microbiota dysbiosis, visceral hypersensitivity, altered intestinal motility, genetic\/epigenetic factors, and psychological influences.<\/p>\n

1\ufe0f\u20e3 Main mechanisms and causes
\nA. Increased intestinal permeability (\u201cleaky gut\u201d)
\nScientific evidence:
\nIn vivo and in vitro studies show that a significant proportion of patients with IBS-D and post-infectious IBS (PI-IBS) exhibit increased intestinal permeability compared with healthy controls. (PubMed)
\nMolecular alterations:
\nReduced expression of tight junction proteins (ZO-1, occludin) has been observed and is correlated with abdominal pain. (sfera.unife.it)
\nBarrier\u2013microbiota\u2013immunity interactions:
\nAntigens crossing the intestinal barrier stimulate mast cells and immune responses, contributing to symptom generation. (PubMed)
\nNote:
\nNot all IBS patients present with \u201cleaky gut\u201d; in IBS-C and IBS-M, intestinal permeability is often normal. (PubMed)
\nKey articles:
\n1. Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review \u2013 Hanning et al., 2021 (PubMed)
\n2. Intestinal permeability and irritable bowel syndrome \u2013 Camilleri & Gorman, 2007 (PubMed)
\n3. Impaired intestinal barrier integrity in the colon of patients with IBS \u2013 De Giorgio et al., 2009 (sfera.unife.it)<\/p>\n

B. Other pathophysiological causes (IBS without increased permeability)
\nGut\u2013brain axis dysfunction \u2192 visceral hypersensitivity and central pain modulation (NCBI)
\nAltered intestinal motility \u2192 diarrhea, constipation, or alternating bowel habits (NCBI)
\nMicrobial dysbiosis \u2192 fermentation, gas production, modulation of motility and sensitivity (Springer Nature)
\nMetabolic alterations \u2192 serotonin, bile acids (PubMed)
\nPsychological factors\/stress \u2192 modulation of motility and visceral sensitivity (Torrinomedica)
\nMild or immune-mediated inflammation \u2192 mast cell activation or immune signaling without barrier disruption (PubMed)
\nSummary:
\nIBS is multifactorial; symptoms may occur even in the presence of a functionally intact intestinal barrier.<\/p>\n

2\ufe0f\u20e3 Related articles 1\u20136
\nA. Chronic low-grade inflammation and intestinal permeability
\nReviews exploring how intestinal permeability, microbiota, and systemic low-grade inflammation interact.
\n1. Gut microbiota, intestinal permeability, and systemic inflammation (Springer Nature, 2024)
\n2. Intestinal barrier permeability: the influence of gut microbiota, nutrition, and exercise (Frontiers, 2024)
\nKey concept:
\nInflammation may precede increased permeability or coexist without barrier alterations.<\/p>\n

B. Chronic inflammation without increased permeability
\nLow-grade inflammation does not necessarily imply \u201cleaky gut.\u201d
\nProbabilistic model:
\nInflammation may favor permeability changes, but this is not mandatory.<\/p>\n

C. IBS without increased intestinal permeability
\nIBS-C and IBS-M often show normal permeability
\nIBS-D and PI-IBS show increased permeability only in a subset of patients
\nThis reflects pathophysiological heterogeneity and the importance of additional mechanisms.<\/p>\n

D. Causes of IBS without increased intestinal permeability
\nGut\u2013brain axis dysfunction
\nAltered intestinal motility
\nVisceral hypersensitivity
\nMicrobial dysbiosis
\nMetabolic alterations
\nPsychological factors and stress
\nMild or immune-mediated inflammation<\/p>\n

E. Scientific articles on IBS mechanisms without leaky gut
\nVisceral hypersensitivity:
\n1. Visceral hypersensitivity in irritable bowel syndrome (PubMed)
\n2. Visceral hypersensitivity and diagnostic markers in functional gastrointestinal disorders (International Journal of Advances in Medicine)
\nMicrobiota and dysbiosis:
\n3. Gut microbial dysbiosis in IBS: a systematic review and meta-analysis (PubMed)
\n4. Gut bacterial dysbiosis in IBS: a case-control study (PubMed)
\n5. Evidence of altered mucosa-associated and fecal microbiota composition in patients with IBS (Scientific Reports, Nature)<\/p>\n

F. Chronic inflammation without intestinal permeability alterations
\nSeveral studies document that low-grade inflammation may exist alongside an intact intestinal barrier.
\nIt is therefore essential to distinguish between inflammation and increased permeability.<\/p>\n

G. Role of the enteric (ENS) and central nervous system (CNS)
\nIBS is a disorder of gut\u2013brain communication.
\nENS\/CNS alterations modulate motility, sensitivity, and pain perception even when the intestinal barrier is normal.
\nKey articles:
\n1. The neurobiology of irritable bowel syndrome (Nature)
\n2. Irritable bowel syndrome, the microbiota and the gut\u2013brain axis (PMC)
\n3. Focus on the microbiota\u2013gut\u2013brain axis in IBS (Frontiers)<\/p>\n

H. Molecular mechanisms: intestinal permeability, tight junctions, and microbiota
\nReduced expression of occludin, ZO-1, and claudins in IBS-D and PI-IBS patients
\nMicrobial proteases activate MLCK, increasing permeability
\nThese alterations correlate with clinical symptoms
\nKey articles:
\n1. Molecular mechanisms of microbiota-mediated pathology in IBS (MDPI)
\n2. Impaired intestinal barrier integrity in the colon of patients with IBS (PubMed)
\n3. The expression and distribution of tight junction proteins in IBS (PubMed)<\/p>\n

I. Genetic and epigenetic factors
\nGenetic variants (SERT, TLRs, TNF, tight junction proteins) modulate susceptibility
\nEpigenetics: DNA methylation and microRNAs influence barrier function, inflammation, and sensitivity
\nGene\u2013environment interactions explain clinical heterogeneity
\nKey articles:
\n1. Genetic and epigenetic factors in irritable bowel syndrome (PubMed)
\n2. MicroRNA regulation in intestinal barrier function and IBS (PubMed)
\n3. Epigenetic modifications in functional gastrointestinal disorders (PubMed)
\n4. Twin studies and heritability in IBS (PubMed)<\/p>\n

General conclusion
\nIBS is a multifactorial disorder in which increased intestinal permeability, dysbiosis, visceral hypersensitivity, ENS\/CNS alterations, low-grade inflammation, genetic and epigenetic factors interact to produce heterogeneous symptom profiles.
\nUnderstanding these mechanisms enables more personalized and targeted therapeutic approaches for IBS subgroups.
\nIntestinal permeability is only one of several mechanisms present in specific patient subsets, while others\u2014such as motility disorders, microbiota alterations, genetics, and stress\u2014can drive IBS even in the presence of a normal intestinal barrier.<\/p>\n","protected":false},"excerpt":{"rendered":"

Abstract Irritable bowel syndrome (IBS) is a complex and multifactorial disorder that cannot be explained by a single pathogenic mechanism. In recent years, increased intestinal permeability (\u201cleaky gut\u201d) has received considerable attention as a potential contributor to IBS pathophysiology. However, current scientific evidence indicates that barrier dysfunction affects only a subset of patients rather than […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[73],"tags":[2105,2103,2071,1889,2099,1035,2111,1947,947,2113,2107,2109,2095,2097,2101],"class_list":["post-12650","post","type-post","status-publish","format-standard","hentry","category-article","tag-chronic-abdominal-pain","tag-functional-gastrointestinal-disorders","tag-gut-barrier","tag-gut-microbiota","tag-gut-brain-axis","tag-ibs","tag-ibs-d-en","tag-intestinal-permeability","tag-irritable-bowel-syndrome","tag-leaky-gut-en","tag-low-grade-inflammation","tag-personalized-ibs-treatment","tag-post-infectious-ibs","tag-tight-junctions","tag-visceral-hypersensitivity"],"yoast_head":"\nIrritable Bowel Syndrome and Intestinal Permeability: Mechanisms Beyond Leaky Gut - Glutenlight<\/title>\n<meta name=\"description\" content=\"Irritable bowel syndrome (IBS) is a multifactorial disorder. Increased intestinal permeability affects only a subset of patients, while gut\u2013brain axis dysfunction, visceral hypersensitivity, motility disorders, and microbiota alterations play major roles.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/glutenlight.eu\/?p=12650&lang=en\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Irritable Bowel Syndrome and Intestinal Permeability: Mechanisms Beyond Leaky Gut - Glutenlight\" \/>\n<meta property=\"og:description\" content=\"Irritable bowel syndrome (IBS) is a multifactorial disorder. Increased intestinal permeability affects only a subset of patients, while gut\u2013brain axis dysfunction, visceral hypersensitivity, motility disorders, and microbiota alterations play major roles.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/glutenlight.eu\/?p=12650&lang=en\" \/>\n<meta property=\"og:site_name\" content=\"Glutenlight\" \/>\n<meta property=\"article:published_time\" content=\"2026-01-19T07:38:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-01-26T08:39:52+00:00\" \/>\n<meta name=\"author\" content=\"luciano\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"luciano\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"10 minuti\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/glutenlight.eu\/?p=12650&lang=en#article\",\"isPartOf\":{\"@id\":\"https:\/\/glutenlight.eu\/?p=12650&lang=en\"},\"author\":{\"name\":\"luciano\",\"@id\":\"https:\/\/glutenlight.eu\/#\/schema\/person\/ce85ed8d5ff511199b9e80b95af8990d\"},\"headline\":\"Irritable Bowel Syndrome (IBS) and Intestinal Permeability\",\"datePublished\":\"2026-01-19T07:38:25+00:00\",\"dateModified\":\"2026-01-26T08:39:52+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/glutenlight.eu\/?p=12650&lang=en\"},\"wordCount\":2105,\"publisher\":{\"@id\":\"https:\/\/glutenlight.eu\/#organization\"},\"keywords\":[\"chronic abdominal pain\",\"functional gastrointestinal disorders\",\"Gut barrier\",\"gut microbiota\",\"gut-brain axis\",\"IBS\",\"IBS-D\",\"intestinal permeability\",\"irritable bowel syndrome\",\"leaky gut\",\"low-grade inflammation\",\"personalized IBS treatment\",\"post-infectious IBS\",\"tight junctions\",\"visceral hypersensitivity\"],\"articleSection\":[\"Article\"],\"inLanguage\":\"it-IT\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/glutenlight.eu\/?p=12650&lang=en\",\"url\":\"https:\/\/glutenlight.eu\/?p=12650&lang=en\",\"name\":\"Irritable Bowel Syndrome and Intestinal Permeability: Mechanisms Beyond Leaky Gut - Glutenlight\",\"isPartOf\":{\"@id\":\"https:\/\/glutenlight.eu\/#website\"},\"datePublished\":\"2026-01-19T07:38:25+00:00\",\"dateModified\":\"2026-01-26T08:39:52+00:00\",\"description\":\"Irritable bowel syndrome (IBS) is a multifactorial disorder. Increased intestinal permeability affects only a subset of patients, while gut\u2013brain axis dysfunction, visceral hypersensitivity, motility disorders, and microbiota alterations play major roles.\",\"breadcrumb\":{\"@id\":\"https:\/\/glutenlight.eu\/?p=12650&lang=en#breadcrumb\"},\"inLanguage\":\"it-IT\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/glutenlight.eu\/?p=12650&lang=en\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/glutenlight.eu\/?p=12650&lang=en#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/glutenlight.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Irritable Bowel Syndrome (IBS) and Intestinal Permeability\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/glutenlight.eu\/#website\",\"url\":\"https:\/\/glutenlight.eu\/\",\"name\":\"Glutenlight\",\"description\":\"grani con glutine leggero e tollerabile\",\"publisher\":{\"@id\":\"https:\/\/glutenlight.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/glutenlight.eu\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"it-IT\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/glutenlight.eu\/#organization\",\"name\":\"Gluten Light\",\"url\":\"https:\/\/glutenlight.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\/\/glutenlight.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/glutenlight.eu\/wp-content\/uploads\/2026\/01\/Logo-di-Gluten-Light-con-simbolo-solare.jpg\",\"contentUrl\":\"https:\/\/glutenlight.eu\/wp-content\/uploads\/2026\/01\/Logo-di-Gluten-Light-con-simbolo-solare.jpg\",\"width\":1113,\"height\":648,\"caption\":\"Gluten Light\"},\"image\":{\"@id\":\"https:\/\/glutenlight.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/glutenlight.eu\/#\/schema\/person\/ce85ed8d5ff511199b9e80b95af8990d\",\"name\":\"luciano\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"it-IT\",\"@id\":\"https:\/\/glutenlight.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/32520888e50495c97b3dcb1eb9761e897db01ea203f0c45a441dc878d64c05b1?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/32520888e50495c97b3dcb1eb9761e897db01ea203f0c45a441dc878d64c05b1?s=96&d=mm&r=g\",\"caption\":\"luciano\"},\"url\":\"https:\/\/glutenlight.eu\/?author=2\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Irritable Bowel Syndrome and Intestinal Permeability: Mechanisms Beyond Leaky Gut - Glutenlight","description":"Irritable bowel syndrome (IBS) is a multifactorial disorder. Increased intestinal permeability affects only a subset of patients, while gut\u2013brain axis dysfunction, visceral hypersensitivity, motility disorders, and microbiota alterations play major roles.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/glutenlight.eu\/?p=12650&lang=en","og_locale":"it_IT","og_type":"article","og_title":"Irritable Bowel Syndrome and Intestinal Permeability: Mechanisms Beyond Leaky Gut - Glutenlight","og_description":"Irritable bowel syndrome (IBS) is a multifactorial disorder. Increased intestinal permeability affects only a subset of patients, while gut\u2013brain axis dysfunction, visceral hypersensitivity, motility disorders, and microbiota alterations play major roles.","og_url":"https:\/\/glutenlight.eu\/?p=12650&lang=en","og_site_name":"Glutenlight","article_published_time":"2026-01-19T07:38:25+00:00","article_modified_time":"2026-01-26T08:39:52+00:00","author":"luciano","twitter_card":"summary_large_image","twitter_misc":{"Scritto da":"luciano","Tempo di lettura stimato":"10 minuti"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/glutenlight.eu\/?p=12650&lang=en#article","isPartOf":{"@id":"https:\/\/glutenlight.eu\/?p=12650&lang=en"},"author":{"name":"luciano","@id":"https:\/\/glutenlight.eu\/#\/schema\/person\/ce85ed8d5ff511199b9e80b95af8990d"},"headline":"Irritable Bowel Syndrome (IBS) and Intestinal Permeability","datePublished":"2026-01-19T07:38:25+00:00","dateModified":"2026-01-26T08:39:52+00:00","mainEntityOfPage":{"@id":"https:\/\/glutenlight.eu\/?p=12650&lang=en"},"wordCount":2105,"publisher":{"@id":"https:\/\/glutenlight.eu\/#organization"},"keywords":["chronic abdominal pain","functional gastrointestinal disorders","Gut barrier","gut microbiota","gut-brain axis","IBS","IBS-D","intestinal permeability","irritable bowel syndrome","leaky gut","low-grade inflammation","personalized IBS treatment","post-infectious IBS","tight junctions","visceral hypersensitivity"],"articleSection":["Article"],"inLanguage":"it-IT"},{"@type":"WebPage","@id":"https:\/\/glutenlight.eu\/?p=12650&lang=en","url":"https:\/\/glutenlight.eu\/?p=12650&lang=en","name":"Irritable Bowel Syndrome and Intestinal Permeability: Mechanisms Beyond Leaky Gut - Glutenlight","isPartOf":{"@id":"https:\/\/glutenlight.eu\/#website"},"datePublished":"2026-01-19T07:38:25+00:00","dateModified":"2026-01-26T08:39:52+00:00","description":"Irritable bowel syndrome (IBS) is a multifactorial disorder. Increased intestinal permeability affects only a subset of patients, while gut\u2013brain axis dysfunction, visceral hypersensitivity, motility disorders, and microbiota alterations play major roles.","breadcrumb":{"@id":"https:\/\/glutenlight.eu\/?p=12650&lang=en#breadcrumb"},"inLanguage":"it-IT","potentialAction":[{"@type":"ReadAction","target":["https:\/\/glutenlight.eu\/?p=12650&lang=en"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/glutenlight.eu\/?p=12650&lang=en#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/glutenlight.eu\/"},{"@type":"ListItem","position":2,"name":"Irritable Bowel Syndrome (IBS) and Intestinal Permeability"}]},{"@type":"WebSite","@id":"https:\/\/glutenlight.eu\/#website","url":"https:\/\/glutenlight.eu\/","name":"Glutenlight","description":"grani con glutine leggero e tollerabile","publisher":{"@id":"https:\/\/glutenlight.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/glutenlight.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"it-IT"},{"@type":"Organization","@id":"https:\/\/glutenlight.eu\/#organization","name":"Gluten Light","url":"https:\/\/glutenlight.eu\/","logo":{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/glutenlight.eu\/#\/schema\/logo\/image\/","url":"https:\/\/glutenlight.eu\/wp-content\/uploads\/2026\/01\/Logo-di-Gluten-Light-con-simbolo-solare.jpg","contentUrl":"https:\/\/glutenlight.eu\/wp-content\/uploads\/2026\/01\/Logo-di-Gluten-Light-con-simbolo-solare.jpg","width":1113,"height":648,"caption":"Gluten Light"},"image":{"@id":"https:\/\/glutenlight.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/glutenlight.eu\/#\/schema\/person\/ce85ed8d5ff511199b9e80b95af8990d","name":"luciano","image":{"@type":"ImageObject","inLanguage":"it-IT","@id":"https:\/\/glutenlight.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/32520888e50495c97b3dcb1eb9761e897db01ea203f0c45a441dc878d64c05b1?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/32520888e50495c97b3dcb1eb9761e897db01ea203f0c45a441dc878d64c05b1?s=96&d=mm&r=g","caption":"luciano"},"url":"https:\/\/glutenlight.eu\/?author=2"}]}},"_links":{"self":[{"href":"https:\/\/glutenlight.eu\/index.php?rest_route=\/wp\/v2\/posts\/12650","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/glutenlight.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/glutenlight.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/glutenlight.eu\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/glutenlight.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12650"}],"version-history":[{"count":10,"href":"https:\/\/glutenlight.eu\/index.php?rest_route=\/wp\/v2\/posts\/12650\/revisions"}],"predecessor-version":[{"id":12716,"href":"https:\/\/glutenlight.eu\/index.php?rest_route=\/wp\/v2\/posts\/12650\/revisions\/12716"}],"wp:attachment":[{"href":"https:\/\/glutenlight.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12650"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/glutenlight.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=12650"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/glutenlight.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=12650"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}